بررسی پلی مورفیسم ژن APOE در بیماران ایرانی مبتلا به آلزایمر

Background: Alzheimer's disease is a multi-factorial disorder. The genes involved in Alzheimer's disease act as risk factors. The aim of this study was to investigate the APOE gene polymorphism in patients with Alzheimer's disease in Iran. Materials and Methods: In this analytical-descriptive study, 50 patients with Alzheimer's were investigated. Polymorphism of the APOE gene was investigated in healthy subjects and patients with Alzheimer's using Tetra Arms PCR. Results: The frequency of the 4ε /4ε genotype and ε4 allele was significantly higher in patients with Alzheimer's compared to healthy subjects (38/4% and57/4% versus 3/8% and 28/8%, respectively) (P≥0.009). Conclusion: In polymorphism of the APOE gene, the 4ε /4ε genotype, and the ε4 allele, are risk factors for Alzheimer's disease in the Iranian population.